Two years have passed since the last season. Jin and Saki develop a sweet confectionery that contains medicine for Saki's mother who has a severe case of beriberi. Meanwhile, Ryoma asks Jin to care for Kaishuu Katsu's mentor, Shozan Sakuma. Shozan is in a critical state after being attacked by the Shinsengumi. Jin is reluctant because curing Shozan would mean changing the course of history. However, Shozan tells him that he too is involved in the “present”.

The story follows a brain surgeon named Minakata Jin who has spent the last two years in anguish, as his fiancee lies in a vegetative state after an operation he performed. One day, he faints at the hospital and awakens to find himself transported back in time to the Edo Period. He is soon attacked by a samurai, but he escapes with the help of a man named Kyotaro. Kyotaro suffers a serious injury to the head while trying to protect him, but Jin manages to save his life despite a lack of proper medical equipment. Because of that, Kyotaro's sister Saki begins taking an interest in Jin and becomes his assistant. Meanwhile, Jin is determined to find a way back to the present.

Korean emperor Lee Gon tries to close the doors to a parallel world which was opened by demons; a detective tries to protect the people and the one she loves.

A talented doctor travels over 150 years back in time to when the powerful Joseon dynasty ruled over Korea, and uses his skills to save lives in this intriguing fantasy drama. Dr. Jin Hyuk, the 21st century’s best neurosurgeon meets an unidentified patient and passes out while in despair over an accident that his lover Mina has had. As he wakes up, he's suddenly transported to the time of the Joseon Dynasty. When a plague strikes Joseon, Hyuk treats the dying people and makes a new resolution with Yi Ha Eung, who dreams of the reform of Joseon. But Jin Hyuk hesitates to study and practice medicine to out of fear that he might change history forever. Follow the trials and triumphs of this traveling doctor who ends up in the wrong place at the wrong time.

At Snowfall Villa, Xiao Se, a miserly innkeeper who wears an expensive fur coat but can't afford to maintain the inn, meets Lei Wujie, a disciple of the Lei Clan who has just entered the martial arts world. The two decide to roam the martial arts world together. On their journey they meet Wuxin, the young head of Tianwaitian, Sikong Qianluo, the daughter of the Spear Deity of Xueyue City, Tang Lian, the first disciple of the Tang Clan, and Ye Ruoyi, the daughter of the General. However, they are embroiled in the conflicts of the martial arts world and the imperial court. They gradually realize that everything seems to be connected to the innkeeper Xiao Se. When they are together, they seize the Golden Coffin, break through death traps, search for the celestial mountain, fight the most powerful martial artist in the world, and defeat tens of thousands of troops. Xiao Se's true identity also comes to light. All that has happened is related to the battle for the throne twelve years ago...

In Korea’s feudal past, the deposed Crown Prince Lee Heon has been forced into a lonely exile by his cruel older brother, who has usurped the throne. Lee Heon fears for his life at every moment, as his brother plans to secure his place on the royal seat by killing him. Assassins and other schemes are a constant threat for Lee Heon, whose only true ally is his faithful and kind-hearted bodyguard Geum. Meanwhile, in modern times, a high school student named Eun Ho loves paintings. In fact, art is his whole world. And when he is tasked with completing a mysterious painting, he is unexpectedly drawn back into the distant past, where he meets Lee Heon. The duo starts to form a close, romantic, and tender bond. But as the acting king grows restless, hoping to kill the exiled Crown Prince as soon as possible, Eun Ho begins to understand that he may be Lee Heon’s best – or perhaps only – chance of survival...

Karin, a DNA operator from the future, is on a mission to change the course of History by stopping Junta Momonari from becoming the Mega-Playboy who fathered 100 children and led to the overpopulation of the world. But Junta is no playboy; in fact he is allergic to girls. But when Karin shoots him with the wrong DNA-altering bullet, he starts sporadically becoming the Mega-Playboy capable of charming any woman. Karin must try to restore the situation to normal before the change to Mega-Playboy becomes irreversible.