Dr. Mercy tries to remove Price's lipoma, which is so big that it has gotten in the way of his relationship. Ashley's case of neurofibromatosis is one of the worst in the country. Becca was born with a birthmark that covers the majority of her face.

Joseph's neck lipoma gets in the way of everything he does. Rachel's condition gives her a full beard that she shaves daily. Summer has seven cysts, including one she calls her "unicorn horn."

Tiffany has a rare condition that has left her couch bound.

Jorge's case of rhinophyma is so bad that he finds it difficult to breathe.

Ramon's keloids are so large that he may require a skin graft if removed.

Tiana hopes Dr. Mercy can figure out how to get rid of her two extra breasts; Michael wants his giant patches of skin tags removed for his 40th birthday; Chandra's lipoma is weighing her down physically and emotionally.