The PFL 3 mixed martial arts event for the 2022 season of the Professional Fighters League will be held on May 6, 2022, at the Esports Stadium Arlington in Arlington, Texas. This will be the third regular season event of the tournament and included fights in the Women's Lightweight and Welterweight divisions.

Invicta FC 43: King vs. Harrison was a mixed martial arts event. Ir was originally scheduled to be headlined by Pearl Gonzalez and Erin Blanchfield fighting for the vacant flyweight title. Due to COVID-19, the planned title fight was forced to be postponed. The previous co-main event of Emily Ducote and Montserrat Ruiz fighting for the vacant strawweight title was then moved up to become the main event. Stephanie Geltmacher was scheduled to fight Trisha Cicero, but Cicero withdrew the week before the event and was replaced by Caitlin Sammons. The event will also feature the promotional debut of undefeated Olympic judo gold medalist, Kayla Harrison The day before the event, the planned main event of Ducote vs. Ruiz was called off and postponed due to COVID 19. As a result, Kayla Harrison's debut against Courtney King was moved up to become the new main event.