A scientist named Hunter Hawk invents a device that can turn flesh to stone. While celebrating his discovery he becomes involved with a half naked leprechaun. On a trip to New York, Hunter and Meg (the leprechaun) decide to go to the Metropolitan Museum of Art and turn all of the Statues of Greek Gods into people. What follows in a drunken romp around New York with Medusa's severed head still in Perseus' hand.

Doctor Smith and his wife, Mary,depart a riverboat and are met by Phil Talbot. Phil informs Dr. Smith that Jessup, the only other white man in the village, has died while the doctor and his wife were off on a two-day holiday. Unknown to Smith, Jessup and his partner, Ross King, had a large cache of ivory tusks in the jungle, and he had told Phil about it. Meanwhile, Mary Smith has decided to steam-boat down the Congo River to Capetown for an extended holiday. Kuba, King's gun-bearer, asks Smith to write a letter to King, currently residing at a New York City Explorer's Club, and advise him that his partner has died. Talbot sends a letter to his stateside sweetheart, Diane Cameron, and her father, asking them to come to Africa and join him on an ivory-treasure expedition, and replenish their family-fortune lost in the recent stock-market crash. What Mr. Cameron and Diane don't know about Talbot is that his years in Africa have unhinged him...

Claire Tree spends the night in the hotel room of her friend and confidante, saying goodbye to him before her impending marriage the following day. When she returns to the hotel with her husband the following night, the house detective accuses her of prostitution and throws them out. Now Claire must explain everything to her unsympathetic husband.

Based on a novel by William J. Locke, Stella Maris is a remake of the 1918 Mary Pickford vehicle of the same name.