Edo Moiselle is an exhilarating, heart-warming comedy that takes place in Tokyo. It is about a big-hearted Edo era courtesan looking for solace for her weary soul while getting wrapped up into trouble wherever she goes. An entertaining love story that transcends the ages.

Haru is an otaku girl who has no interest in food or clothes—she'd rather spend her money on her own hobbies. This changes when she meets a genderless boy, Ao. Their story begins with them creating delicious bento boxes together.

Koichi Miyazawa runs a small, but longstanding company which makes tabi (traditional Japanese socks). He is the CEO of the fourth generation company with about 20 employees. Due to a decrease of demand for tabi, the company is struggling to keep afloat. Koichi Miyazawa thinks about launching a new product line. The new product is running shoes. For the company's surival, Koichi Miyazawa begins to develop running shoes using their accumulated knowledge for making tabi.

Akira is a normal high school boy, but he nevertheless impulsively licks some drool left by the mysterious transfer student Mikoto. The next day he falls asleep with an inexplicable fever. After five days Mikoto suddenly comes to visit, and makes him consume her drool. The fever instantly vanishes, and Mikoto explains that he's suffering from "love sickness." She can transmit emotions through her drool, and the two of them are now bound together.

Oomae Haruko is an A+ Temp worker who never cracks a smile or minces words, and leaves work on the dot. But her cynical nature indicates she has something painful to hide. Satonaka Kensuke has just been promoted to head S&F's new Marketing Division. Saddled with a rag-tag group of subordinates, he is struggling to lift his division off the ground. When Oomae is placed in Kensuke's department, she finds herself doing more work than she's ever done before. This is a timely drama that examines the different attitudes toward temp workers and regular employees, and the ways to overcome frictions in interpersonal relationships. This follows an October report on labor conditions by the Labor Ministry, which showed that, after regulations were relaxed, the proportion of regular employees to Temps had doubled compared to that of eight years ago.