65 year old doctor Pierfrancesco works as a night-shift medical guard. He’s a grumpy man, full of aches and pains and is very rough with his patients. One night, he’s involved in a road collision with 30 year old delivery man Mario. While uninjured, Mario's bicycle is destroyed, and Pierfrancesco's sciatica flares up, making it impossible for him to drive. With both of their jobs in jeopardy, the doctor has an idea that could help them both: “remotely guided” by Pierfrancesco via wireless headset, Mario will visit his patients, and they’ll also carry out Mario’s delivery in Pierfrancesco’s car. After a range of daring (mis)adventures, they will learn to support each other, and the night will end with their lives both changed for the better.

The story is about Eva, a Ukrainian girl who has come to Milan to work as a model. As soon as she arrives in Italy she attracts the attention of the male world. All of the men that she encounters seem to be solely interested in exploiting her beauty: and so we have Luke, the stalker, who never stops tormenting her with text messages and phone calls; Airoldi, the shady television producer, who offers her various jobs in exchange for her sexual favours, and lastly, Tom, a vile photographer, who has no scruples whatsoever. After being raped at a party by Tom and two of his colleagues, Eva is invited by Cindy, her flatmate, to a sort of Sabbath, attended solely by women, in a place outside Milan. From that moment on, the gateway to success in the fashion world opens before Eva and, at the same time, a tremendous vendetta begins against the violent male world.