The movie follows Ananthan (Tini Tom), a 36-year-old police constable who has experienced multiple failures at trying to find a woman to marry. He eventually meets and marries Emily (Jyothirmayi), a textile worker, much to the chagrin of both of their families. The couple tried for a baby in the hopes of placating their family, but were unable to conceive and began a series of fertility treatments. Initially overjoyed when the treatments are successful, Ananthan and Emily are shocked to discover that she was now pregnant with quadruplets.

Little did good Samaritan, Mahadevan realize that he was walking into trouble when he takes Radhika, an accident victim to the hospital and is approached by her friend Meera!

The film opens with a ‘Manthravadi’ (Thilakan) an evil magician (Pithamagan Mahadevan) to obey to his commands and make spiriting away a friendly ghost money through crime. Meanwhile a group of kids and their benefactors are held hostage in a circus camp by the baddies, who has taken over the show. Ancy (Kaavyamadavan) is coming back from London, to take charge of the circus company founded by her father Philipose (Janardhanan),who was found murdered. On reaching there, she is told that her father was stabbed to death by a bike-jumper named Jimmy (Mammootty). In fact Jimmy, his foster father Krishnan (Innocent), aide Sisupalan (Suraj Venjarammood) and a gang of street children were all invited by Philipose to join his circus group. Meanwhile the ghost (Mammootty, in his other role) appears, becomes friendly with the kids and takes a more stylish shape of Jimmy. Thanks to the ghost, Ancy realizes that Jimmy was innocent in the whole issue. Now the battle between the good and evil.

My Big Father is about a father and son, where the father is a dwarf.

Bhaskar, a stuntman, is smitten with Cinthya, a college student. However, his heart is broken when he learns that she doesn't love him back but he still to tries persuade her.