This film had a somewhat interesting premise, and clever metaphors in the sense of what parts of the body did what if it were all a city, but it's overall not a great movie. And some of the live action sequences and scatological jokes honestly just nauseated me. Something about seeing the camera zooming in on a filthy, grungy-looking Bill Murray's mouth as he chewed a boiled egg he picked up off the ground made me never want to eat again. I also dislike most of the voice acting, and the live action and animation dissonance seemed unnecessary. Maybe if the whole thing was animated, they could've pulled something interesting off. Overall, it's not recommended. They had a good idea, went way too gross of an angle with it, and ultimately fell short of what they could've done with teaching about how the human body works and whatnot.

While, this animation movie might appeal to somebody with somewhat bad taste like me. The truth is, that the film doesn't work for everybody. Don't get me wrong, there were plenty of somewhat sophistical & adult-driven clever pun-entertaining moments in the animation sequences directed by Tom Sito if you like this movie & the animation wasn't half bad, even if the very noticeable poor early CGI mixed with hand-drawn, made this film, a bit dated. It was still somewhat beautiful. However, the life-action, unfunny childish toilet humor sequences from the Farrelly brothers, kinda dumb down, the film to standstill. Because of that, I can't say, this movie is a good movie. Nevertheless, I also can't say, it's awful. It's somewhat in the middle. Still, there is plenty of flaws in the film to point out. One of the biggest complains of the movie produced by Warner Bros, is the fact that the life action scenes with Frank Detorre (Bill Murray) doesn't intermixed well, with the hand-drawn animation in his body. It's kinda jarring to see, actors reenacted short scenes on camera film footage, only to be badly edited into a film, mostly, full of animation cels. In my opinion, the whole movie should be, all animated! Yes, I know, it would be, more expensive to produce, but at least, the movie would had been, a little more, well-made. Another problem between the live action and animation parts is the pacing. While, the animation move in a pretty solid action pack pace, with white blood cell, officer Osmosis Jones (Voiced by Chris Rock) having to team up, with a cold pill, Drixenol "Drix" Koldreliff (Voiced by David Hyde Pierce), in order to stop a deadly virus, known as Thrax (Voiced by Laurence Fishburne) from killing Frank in a pretty generic buddy cop clichés storyline. I really didn't care for the repetitive gross out and pointless dialogue scenes that they gave Bill Murray to do. Honestly, without spoiling the movie, too much, there was no reason, why Frank needed to reenact with comedian, Molly Shannon's character, as she wasn't any help nor a major foe for Frank. The film would be, better off, without her. Have the film establish, that Jones accidentally causing the death of Frank's wife, by allowing a virus to escape Frank's body, instead of him, causing the vomiting at the science fair, that got Frank in trouble. At least, the movie would had more stalks, plus it would be a better backstory and reason, why the depressed Frank is letting himself go, health wise than what the film gave Murray, with Frank being annoying clueless and too unlikeable lazy at being healthy. Also, I think the movie would had made more sense, if Frank was working at a desk job at the zoo, rather than the field. Why? It's because, it just hard to believe, that Frank would be, really that unhealthy with all the manual back breaking work, he does, like shoveling and washing animals in the hot sun. A desk job works better, because of the lack of physical activity. Sadly, the movie doesn't do this, and the live action scenes really dragged. Honestly, the whole conflict with Frank, choosing a trip to Buffalo over his daughter, Shane (Elena Franklin) camping trip was also not needed. Regardless of him, going or not, Frank's health would had still decline, due to Thrax. Also, with all anthropomorphization aside, anyone who's passed a biology class knows that germs & viruses don't work even remotely like they're depicted in the film. Though they can be harmful to the host that they infest, they aren't biologically programmed to quickly kill it. They mostly reproduce by multiplying and spreading throughout its body over time, feeding on the resources. Any harmful symptoms are simply side-effects of over population and damage of cells. Regardless of the artistic license with the science. Laurence Fishburne was amazing as the villain. The things, his character does, is very haunting and his voice acting matches that. It really surprised me, that's this movie was PG, seeing, how Thrax rips, another germ apart, and cause, a saliva boat to explode in flames. I thought, it would be, at least, PG-13, due to the violence and bodily humor. It didn't help that the lyrics to the Kid Rock's song wasn't kid-friendly as well. This movie is surely, not PG! Gross humor, aside, I didn't like, how the film handle the mentally handicap, obesity, and other issues. Regardless of the botch crudely done moral message, 'Osmosis Jones' is still truly imaginative, innovative and fun with alright voice acting work, even if main star, Chris Rock was a bit annoying with all his standard, generic cockiness, yelling. Still, I felt like I need a detox, after watching this film. Like Junk Food, films like this, should make up a minimal part of your life. Not fully. For the sake of your loves ones. Just stick to healthy & smarter animation choices like 2015's 'Inside Out'. But if you want to junk out on something really childish. Then, you got this film. This autopsy of a mess.

Osmosis Jones (2001): Dir (live): Bobby Farrelly, Peter Farrelly / Dir (animated scenes): Piet Kroon, Tom Sito / Cast: Bill Murray, Molly Shannon, Chris Elliott, Elena Franklin / Voices: Chris Rock: Creative and unique animation. Bill Murray plays an out of shape father who is constantly warned by his daughter to watch his eating habits. Soon a deadly virus begins to spread throughout his body. It is up to animated blood cell Osmosis Jones and his partner Drix to destroy evil virus Thrax. Live footage is directed by Peter and Bobby Farrelly who are famous for great comedies such as Kingpin and There's Something About Mary. Animated sequences are directed by Piet Kroon and Tom Sito who are given the best part of the film. Animated characters are cool and carry the film but the live performances are flat. Bill Murray holds his own as this unhealthy eater who ends up in the down and out and must rely on Jones to triumph and recreate his health. Molly Shannon has the misfortune of having a zit explode on her face. Chris Elliott has a cardboard role of Murray's brother and co-worker. Elena Franklin is flat as Murray's daughter who cares for her father and his welfare. The voice talents fare much better with Chris Rock leading the way as the free spirited Osmosis Jones whose mission is to render Bill Murray healthy. Creative and well meaning comedy about responsible living. Score: 7 / 10

Good Animation, Nicely Voiced and With An Interesting Story, Osmosis Jones is a mediocre unique type of a animated movie which is good for time-pass and can entertain you with its mind-boggling but unique and satirical story about the human body along with nice Voice acting by Chris Rock(who was very good) and Lawrence Fishburne and decent effort from the directors Bobby and Peter Farrelly.The Story is quite unique about the body of Frank Detorre and what takes place in his body which is full of oily and harmful junk food which he consumes on a daily basis, and how the protective cells in the human body fight to destroy the bacteria and virus's which come into the body through the food. The Main Character is Osmosis Jones(Chris Rock), who is a cop cell who always manages to run into trouble and harm Frank's body and he tries to become famous by defeating the harmful virus which wants to kill Frank with his partner Thrax(Fishburne).The Voice acting by the lead actors are very good and they have successfully synchronised their voices with their characters and helped in making the characters look very real! Chris Rock and Laurence Fishburne have done a good job along with William Shatner. They Really put in their best efforts to make their respective characters look real and the characters they've voiced for are the most entertaining of the lot. The Others have also done a decent job in giving voice of these interesting cells and virus's.The Directors Bobby and Peter Farrelly have done an okay-ish job with their crew and have done and tried their best to make this movie very good, but it has its flaws, but you have to give them credit for doing their best. They did a good job with the voicing of the characters and helping the actors blend in with their characters and have made this movie a good one for time-pass.The Story of this movie is quite unique and its a good satirical dig at what happens inside the human body and they have tried to show the importance of these protective cells in destroying the virus's and helping us keep healthy and from getting diseases. The Writer Marc Hyman has done a great job in making this uniquely good script and because of the story this movie is quite worth the watch and worth your time.The Animation team has done a great job in showing all these protective cells and them destroying the virus's and how they ''live'' inside the human body and the animation is spot on in this movie and the animation team has really done their best in giving the audience a good time with this entertaining animation and these interesting characters.Well, if your quite bored and have nothing to do, you can try and watch this movie for time-pass and you will find it quite decent with its interesting story and colourful characters, but if your looking for a serious movie, pass this.My Rating: 6.3/10