Lifting the lid on the night shift as experienced by A&E workers, with exclusive access to Hull Royal Infirmary. The night-time challenges facing NHS staff are captured in their raw form.

In North London security must manage an abusive man as he refuses to leave, despite being discharged and a patient suffering from a heroin overdose is rushed to Rotherham General Hospital’s resus. Coming to his wit’s end with a severe toothache, patient Kieran’s abscess spreads to his airways and Doctor Mehran must decide whether he needs emergency surgery. Plus, security guard Justin suffers a head wound after being attacked when he tried to prevent a theft at his work.

During an A&E nightshift in South Yorkshire nurse Luke treats a man who's developed a bleeding haematoma. After becoming involved in an altercation a young man suffers a gash on his forehead which nurse Ayaan treats, sending him for an in-depth cranial examination. In Rotherham, Doctor Bethany sees to a patient with and neck injuries due to a car crash on a country road. At the North Middlesex University Hospital police bring in a patient who is under arrest, staying with him while he is being triaged to ensure the safety of staff. In Tunbridge Wells as 85-year-old Mo injures her wrist after having a fall, X-rays reveal that her wrist is fractured meaning a lengthy recovery for Mo. Plus, towards the end of the nightshift in Rotherham an unresponsive man is brought into resus by paramedics. Doctor Ed and Nurse Gemma must work fast to stabilise the patient, suspecting he is a diabetic and has suffered a stroke.

In Rotherham's A&E a patient with a suspected head injury is under arrest in the car park. In London, an eye injury from mixing concrete requires action to prevent permanent damage.

In Tunbridge Wells A&E an ambulance crew bring in a patient who is behaving aggressively, sister Geraldine calls security, but the patient takes off, refusing treatment. At North Middlesex University Hospital, a patient's heart stops beating, so the team tries to save their life and maintain blood flow to the brain. At the North London Emergency Department, a 45-year-old suffers life-threatening anaphylaxis from an allergic reaction.

Nurse Simone has a drunk patient and his equally drunk friend who have passed out in a cubicle, Nurse Sheena must examine a 50-year-old man's puncture wounds from a dog attack. Dr Kaylee is working quickly to investigate a suspected broken ankle, and Dr Luke is concerned with a patients breathing difficulties, who has been brought into resus in a diabetic coma.

A man is rushed in to Majors suffering with a collapsed lung and air is leaking into his chest cavity, a highly abusive patient must be restrained, and a rough sleeper comes in with burnt feet.

Police bring in an abusive male under arrest who claims he has a racing heart, and two friends arrive in resus who have dislocated each other's shoulders during a friendly wrestle.

Overnight in Rotherham's A+E always sees regular patients making an appearance. A man has been rushed in, escorted by police with a suspected overdose. Nurse Sophie and the team must race to treat and calm the patient before he begins his usual disruptive shenanigans.

A+E Departments are seeing alcohol abuse on the rise and in Rotherham an alcohol-dependent patient arrives at the rapid assessment unit after faceplanting onto concrete. The patient is agitated but Dr Alex's primary concern is spinal damage and brain injury. They transfer the patient to resus just in time to intercept a seizure. Time is critical but this patient's behaviour is getting in the way of a life-saving brain scan.

A&E in London's North Middlesex University Hospital is heating up thanks to an aggressive male who claims he has been attacked. Language is a barrier but by a stroke of luck, Advanced Clinical Practitioner Albena translates. The patient is incoherent, threatening, and is a risk to others, so security stand close until his suspected psychosis can be managed.