The life and career of the renowned voice actor of animation and radio. For generations, Mel Blanc was one of the most famous Hollywood voice actors with his myriad of voices for classic animated characters like Bugs Bunny, Daffy Duck and scores of others. However, animation was only one of the fields where Blanc shone through in his long career. This film covers the life of this amazingly talented and big hearted actor, comedian and musician as he became one of the performing greats from the golden ages of American animation and radio through to the 1980s.

The major sub-plot circles around the youngest Griffin, Stewie, who has a near-death experience at a pool when a lifeguard chair falls on him, but he survives. After having a vision of being in Hell, he decides to change his ways, but this doesn't last long. While watching television, he and Brian spot a man that looks like Stewie. Brian is convinced that he is Stewie's real father, until Stewie learns that the man is actually himself as an adult, taking a vacation from his own time period. Baby Stewie visits thirty years later to discover that his adult self, going by the name Stu, is a single blue-collar middle-aged virgin working at a Circuit City-type store. Meanwhile, Peter and Lois are trying to teach their two older kids, Meg and Chris, to date. In the future, Chris, who hasn't changed much, is working as a cop and is married to a foul-mouthed hustler named Vanessa. Meg is now called Ron, since she had a sex-change after college.