River Miller, a mentally unstable actor haunted by the past, moves to Hollywood to start his life over, only to find his inner demons are inescapable.

Karen is shopping at a convenience store during which a robbery occurs. Her niece is kidnapped and left seriously injured in hospital. When one of the perpetrators is released, Karen decides to go on a murderous trail of revenge.

In the near future, everything has changed. Basic human rights have become the rarest of luxuries. No one knows when this started but everyone knows how. The VXII, the deadliest virus ever created, spread like wildfire and decimated the majority of the world's population. The non-infected survivors now cling to life in four quarantined cities behind a wall. Shawn Kors and his brother, Jude, survived the VXII only to grow up in a squalid internment camp for orphaned children. Under the care of the militia, they were pitted against other children in backwoods death matches. Shawn, Jude, and the few who escaped became notorious for their incredible fighting skills. They have since parted ways. Shawn now makes a comfortable living as a janitor at the local medic station. He spends his days dreaming of curing the VXII. When Shawn discovers the discarded body of a fellow internment camp friend, he is forced out of hiding and pulled into a rabbit hole of conspiracy and violence.

Two down and out strangers are brought together by mysterious letters into a safe house as the world around them is infected by an experimental virus that transforms the living into the living dead. She is a former prostitute hiding from the world. He is a former assassin turned priest who has renounced violence. Together they must unravel the mystery of the letters if they hope to survive.

Two fathers' lives intersect when one of them is involved in a terrible and sudden hit-and-run car accident that leaves the other's son dead. In response, the two men react in unexpected ways as a reckoning looms in the near future.