Nino and Caterina have been married for 65 years. After Caterina's death, their daughter Elisabetta, trying to help her father to overcome the loss, hires an author to write a book on their love story.

Candida is a fifteen year old from Sicily, who lives with her father Salvo. When he loses his job, they leave for Turin. Candida has to integrate in a new school where she is bullied, as does her partner Jacopo. But thanks to her positivity, it will be Candida who will let Jacopo out of his isolation, making him discover that everything is good, even when it is not great.

For John Cuttin it all started with the first sip of the wine of her life. A "Marzemino", a typical wine of the province of Trento, quoted by Lorenzo Da Ponte in his libretto for "Don Giovanni" by Mozart. The instant he tasted the blood-red drop of nectar John felt a sort of pleasant and mysterious explosion of the senses, and from that moment on, his nature is transformed. In just three years, from shy bank clerk and faithful husband became director, tombeur de femmes and the most revered and respected expert on wine in Italy. Just as he had predicted the enigmatic "Professor" who had convinced him to taste his first glass of wine. The only event that the "Professor" with his accent and his piercing blue eyes, had not predicted was that he would soon be charged with the murder of his wife Adele. While being put under pressure by the Commissioner Sanfelice, John is to reflect on the last three years of his life, dominated by a single and mad passion: wine.