A budding love story between a medical student and a nurse takes place in May 1980, during a time of civil unrest and military oppression in Gwangju.

An old stately inn stands in the heart of Seoul. It may be old, discolored, and weathered, but Nakwon Inn exudes old-world charms. As the typical cold uneventful winter comes to an end at the inn, guests start to arrive one by one as if each had promised to be present. Strangely and coincidentally, each one of them repeats Never Twice as they enter. The truth is, they all have a fateful reason to be there. What could have brought these individuals together? And what do they all have in common considering their long-term stay, assigned room numbers, gender, age, and hometown? The real reason for coming to Nakwon Inn unfolds.

Set during the period of the 1894 Donghak Peasant Revolution against the Japanese, the drama tells the story of two half-brothers, one illegitimate and low born, and one, part of the pro-Japanese ruling elite, who find themselves on opposite sides of the conflict.

A wingless fairy awaits the reincarnation of her former husband to try to locate her lost wings and return to heaven. Sun Ok Nam is a fairy who came down to Earth to take a bath during the Joseon Dynasty. A woodcutter steals her clothes, and she is unable to return to heaven. She decides to marry the woodcutter and has two children with him. But before she can find out where he hid her clothes, the woodcutter dies in an accident. Almost 700 years later, Ok Nam works as a barista in a café, awaiting the reincarnation of her woodcutter husband. To most people who see her, Ok Nam looks like an old woman, but some people can see her for her youthful beauty. When two men, Jung Ji Hyun and Kim Geum, come into the café one day, Ok Nam is convinced that one of them is her reincarnated husband. Can Ok Nam finally find her lost clothes and return to heaven?

Im Chi-Woo never wanted to become a good daughter, a good daughter-in-law or a good wife, but she sacrifices herself to take care of her family. She is married to immature Park Wan-Seung and she works several part-time jobs to support her family. Under her difficult situation, she keeps smiling and maintaining her positive attitude. Choi Jin-Yoo is a divorcee and he has a daughter. He works hard and tries live positively for his daughter. He encounters a nightmare like scenario.

Byeon Hyeok is the younger son of a rich conglomerate family who was born with a silver spoon in his mouth. The lack of difficulties in life contributed to the carefree and hopelessly positive mindset of his. One day, he meets a girl who is everything that he is not. This drama is a depiction of youth where they learn about love and friendship.

In-Sung has prepared for the examination to become a police officer for 4 years. He has failed the exam 8 times, but he still has a positive personality. He then applies for the high pay part-time job which is titled "Experiment Full of Life."