Ozzy & Drix, also known as The Fantastic Voyage Adventures of Osmosis Jones & Drixenol and Osmosis Jones: The Animated Series, is an American animated television series based on the Warner Bros. film Osmosis Jones and it was produced by Warner Bros. Animation. It takes place inside the body of teenager Hector Cruz. The series premiered on September 14, 2002 on the Kids' WB; the final episode aired July 5, 2004. Unlike the original movie it spun off from, Ozzy & Drix was entirely animated and contained no live action. It stars Phil LaMarr as the replacement for Chris Rock as Osmosis Jones, and Jeff Bennett as the replacement for David Hyde Pierce as Drix. As of July 2011, episodes of the series are still available via the Kids WB website. The show also aired on Teletoon in Canada. The show is also slightly less violent than the movie, having the characters treated like people rather than simply cells, and having none of them killed off, unlike the movie where Thrax managed to kill off several cells. There are also new characters that replace the ones from the original movie such as Maria Amino replacing Leah Estrogen, Mayor Spryman replacing Mayor Phlegmming, Sylvian Fischer replacing Tom Colonic, Chief Gluteus replacing The Chief of Police, The Mole replacing Chill the Flu Shot and Scarlet Fever replacing Thrax.

Desperate for a job to help him support his family, Jim Norman takes a position teaching high school in the town where his brother was murdered in front of him by teenage bullies twenty-seven years before. The teens who committed the crime are long dead, but now the kids in Jim's new class keep dying and being replaced by new students who look like the deceased hoodlums.

After Leila, his boss's daughter, is kidnapped by psychopathic plague victim Decker, chauffeur Chazz teams up with plague-infected mercenary Luger to penetrate the toxic & off-limits Plague Zone and bring her back alive.

Denny has yet again been left by her thug boyfriend Chip. It seems as if she is doomed to be stuck with awful guys, this time she has to choose between nerdy Charles and the strange Kaz, who turns into a monster when sexually aroused.

Garvey is a San Francisco pawnshop operator. His unemployed and criminal friends Dillard, Turtle and Weslake, team up with Boardwalk, a local pimp, to burgle Garvey's shop while the owner is out of town. During the elaborate planning process, Dillard falls for a Hispanic woman, the sister of a friend. Boardwalk is assigned to case a local apartment, where he meets and falls for the maid. Amidst all these romantic hijinks, Weslake puts together a burglary plan, which is executed by the makeshift gang.