This is the continuing saga of the Cartwrights, only none of the original Cartwrights are here anymore but their sons. Ben and Hoss have passed on, and Little Joe is MIA; he went with Teddy Roosevelt and is currently missing. Ben's brother, Aaron is now in charge of the Ponderosa, and Little Joe's wife Annie also lives there. His son, Benjamin has come back fom the East. Charlie Poke is a man who owes his life to Ben Cartwright and is now the ranch foreman, and is not exactly on good terms with Aaron. Aaron has allowed a mining company access to mine on the Ponderosa, but the man in charge has other ideas. And Hoss' son Josh whom no one has seen before, has come to the Ponderosa to kill Hoss cause he thinks Hoss deserted him and his mother not knowing that Hoss died before he could go back to bring his mother back to the Ponderosa.

On its maiden flight, the crew of America's first supersonic transport learns that it may not be able to land, due to an act of sabotage and a deadly flu onboard.

Colonel Steve Austin, astronaut and test pilot, is badly injured when he crashes while testing an experimental aircraft. A covert government agency (OSI) is willing to pay for special prosthetics to replace the eye, arm and both legs he lost in the crash. Highly advanced technology (bionics) built into them will make him faster, stronger and more resilient than normal. In return they want him to become a covert agent for the OSI. It will cost $6,000,000 to rebuild Steve Austin.

A young couple inherits an old mansion inhabited by small demon-like creatures who are determined to make the wife one of their own.

When an assassin's bullet confines him to a wheelchair for life ending his career as Chief of Detectives, Robert T. Ironside becomes a consultant to the police department. Detective Sergeant Ed Brown and policewoman Eve Whitfield join with him to crack varied and fascinating cases. Ex-con Mark Sanger is employed by the chief as home help but eventually becomes a fully fledged member of the team also. Officer Whitfield leaves after 4 years service, and is replaced by Officer Fran Belding.

Citizens of San Francisco are stunned by the news that Robert Ironside, the city's hard-nosed, tough-talking chief of detectives, has been shot and left for dead while vacationing at his friend the Police Commissioner's rural retreat. Ironside survives the murder attempt, but the bullet has damaged nerves in his spine, leaving him a paraplegic. Unable to gain reinstatement as chief of detectives, Ironside gets permission to continue investigating criminal cases as a citizen volunteer. With the assistance of two former protegees, Det. Sgt. Ed Brown and Officer Eve Whitfield, and a newly-hired aide/driver, Mark Sanger, Ironside sets out to solve his first case as a civilian by finding the people responsible for the attempt on his life.